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31.
针对服务代理采用的现有数据中心选择算法存在系统性能低和总体成本高等问题,提出一种基于优先级的轮询服务代理算法。该算法对数据中心的优先级进行定义,并根据数据中心的优先级选择数据中心。通过基于CloudSim仿真器的实验,结果证明该算法比现有数据中心选择算法拥有更好的性能。 相似文献
32.
K. S. S. Saibaba P. V. L. N. Srinivasa Rao K. V. Dakshina Murty M. Vijaya Bhaskar 《Indian journal of clinical biochemistry : IJCB》1997,12(2):139-141
Selecting the correct method for routine analysis by ‘method evaluation’ is an important component of quality assurance. It
is a step-wise procedure that evaluates various analytical parameters like accuracy, precision etc of the given method. Finally
reference intervals are established for selected population. We evaluated an enzymatic method for serum creatinine. The results
show that it is an acceptable method based on the above mentioned criteria. 相似文献
33.
34.
Knowledge discovery systems can be traced back to their origin, artificial intelligence and expert systems, but use the modern technique of data mining for the knowledge discovery process. To that end, the technical community views data mining as one step in the knowledge discovery process, while the non-technical community seems to view it as encompassing all of the steps to knowledge discovery. In this exploratory study, we look at medical knowledge discovery systems (MKDSs) by first looking at three examples of expert systems to generate medical knowledge. We then expand on the use of data abstraction as a pre-processing step in the comprehensive task of medical knowledge discovery. Next, we look at how performance of a medical knowledge discovery system is measured. Finally, the conclusions point to a bright future for MKDSs, but an area that needs extensive development to reach its full potential. 相似文献
35.
36.
G. N. Raval L. J. Parekh D. D. Patel F. P. Jha R. N. Sainger P. S. Patel 《Indian journal of clinical biochemistry : IJCB》2004,19(2):60-71
Sialic acid, the end moieties of the carbohydrate chains are biologically important and essential for functions of glycoconjugates
and are reported to be altered in cancer patients. Two hundred and twenty five breast cancer (BC) patients, 100 patients with
benign breast disease (BBD) and 100 healthy females (controls) were enrolled for the study. Eight hundred and twenty four
follow-up samples of 225 breast carcinoma patients were also evaluated. The association of sialic acid forms, sialyltransferase
and α-2–6 sialoproteins levels with presence and extent as well as prognosis of breast carcinoma was studied. Serum sialic
acid forms and sialyltransferase revealed significantly elevated levels among untreated breast cancer patients as compared
to the controls, patients with BBD as well as cancer patients in remission. Non-responders showed comparable levels of the
markers with those found in breast cancer patients at the time of diagnosis. Higher levels of sialic acid forms at diagnosis
were associated with poor prognosis. A positive correlation between serum levels of different forms of sialic acids and extent
of malignant disease was observed. The changes in serum proteins with terminal α-2–6 sialic acid correlated well with alterations
in the levels of sialic acid forms and sialyltransferase. Malignant tissues showed elevated levels of sialic acid and sialyltransferase
as compared to surrounding normal tissues.
The results suggested potential utility of these markers in evaluation of clinical outcome. 相似文献
37.
38.
Case histories were compiled of 100 instances of technological change in 102 manufacturing companies in eight industries in Ireland, Spain and Mexico. The cases are analyzed for the source of initial ideas and for sources of technology employed in resolving major problems.Technology is found to flow principally through informal channels within industries. Very little information was obtained from the formal mechanisms or institutions normally considered central to the technology transfer process.Foreign subsidiaries obtain the greatest proportion of their technology from their parent firms. Surprisingly, they are found to have several channels of technology blocked to them, which are more readily available to domestic firms. Domestic firms, in many ways have easier access to foreign technology than do the subsidiaries of multinational firms.Product and process innovations originate in somewhat different quarters. Process innovations are slightly more likely to be based on foreign technology; product innovations are more likely to be based on domestic technology.The results reported in the present paper are very similar in many ways to results reported previously in Brazil and Australia. 相似文献
39.
AIM To filtrate breast cancer resistance protein(BCRP)-mediated resistance agents and investigate the mechanism,so as to provide valuable datum for optimization clinical chemotherapy scheme to tumor with evaluation marker of BCRP expression. METHODS MTT assay was used to filtrate BCRP-mediated resistance agents with PA317/Tet-on/TRE-BCRP cell of different expression levels of BCRP after treated with different concentration anticancer agents. High performance liquid chromatography(HPLC) was applied to measure relative dose of intracellular retention resistance agents. Nuclear DNA fluorescence dye,Hochest 33258, staining and flow cytometry were adopted to detect apoptotic cells after treated with drugs. RESULTS There were shown increasing durg-resistance to 5-fluorouracil,methotrexate, doxirubicin, pirarubicin,etoposide and mitoxantrone followed with increasing expression of BCRP on PA317/Tet-on/TRE-BCRP cells(P<0.05, n=3),but shown sensitive to paclitaxel, cisplatin, vincristine, mitomycin and vindesine. There also was shown significant negative correlation between the intracellular retention dose of 5-fluorouracil with different expression of BCRP(r=-0.885, P<0.05, n=3).There were shown parallel results of that decreasing cellular apoptotic rate with increasing cellular expression of BCRP after treated with 5-fluorouracil by fluorescence dye staining and flow cytometry(P<0.05, n=3),and also shown significate rise of the apoptotic rate of BCRP expression cells after treated with Ko143 (P<0.05, n=3). Every group of cells could be different extently blocked in phase of G0/G1 treated with 5-fluorouracil. CONCLUSION Resistance of 5-fluorouracil could be especially mediated by conjugated with BCRP and acted as drug exclude-pump substrate. Cellular ability resistant to 5-fluorouracil-induced apoptosis could be reinforced by BCRP expression. 相似文献
40.
Design of detectors for strong mixing signals in strong mixing noise is considered, where a large degree of dependency may occur between the signal and noise. Under the criterion of asymptotic relative efficiency, it is shown that this design reduces to determining the solution of an integral equation, where only knowledge of the second order statistics of the randon processes involved is required. In particular, if the signal is independent of the noise and has nonzero mean, the optimal detector is the same as in the known constant signal case. It is also shown that it is possible to delete several regularity conditions which may be difficult to check in practice in the slightly more restrictive case where the maximal correlation coefficients of the signal and noise tend to zero. 相似文献